MIDSUMMER SYMPOSIUM ON THE MOLECULAR BIOLOGY AND IMMUNOLOGY OF HCV

JULY 13-15, 2000

Discussion leaders (given in parentheses) will briefly introduce the subjects and raise specific questions for discussion. Discussants may use slides or overheads.

I.  MOLECULAR BIOLOGY; Eckard Wimmer, Chair

II. The cellular receptor for HCV: one or many (Fred Prince)

III. The genome I: genetic variation and sequence clusters (Jens Bukh)

IV. The genome II: Significance of primary and secondary structure for protein synthesis and genome replication; Is there evidence for recombination of viral genomes? (Stan Lemon)

V.  Genome replication: De novo vs. primed initiation of RNA synthesis; Role of cellular and viral proteins in genome replication (Eckard Wimmer)

VI.  Infectious cDNA, replication and host range: Cellular restrictions for replication in cell culture, discussion of the Bartenschlager experiment (Charlie Rice)

VII. Small animal models (Linda Andrus)

I.  IMMUNOLOGY; Jay Berzofsky, Chair

1.  Correlates of self-limitation in HCV infection; Relative roles of CD4 and CD8; Role of host HLA (Gerd Pape)

2.  Progress towards the design of HCV vaccines (Jay Berzofsky/Steve Feinstone)

3.   Enhancement of affinity of epitopes by amino acid shuffling: Pros and Cons (Jay Berzofsky/Alex Sette)

4.  Insights gained by tetramer analysis (Paul Klenerman)

5.  Role of cytokines in immunization/immunotherapy (Kendall Smith)


 

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